Rat Plasmas
Cayman Chemical TrIsACTAte EDTA Stock Solut 1L
An antiemetic and antagonist of dopamine D2- D4- and D3 receptors (Kis 1365 691 and 545 nM for a2A- a2B- and a2C-AR respectively) has been mistakenly identified as an antagonist of histamine H1 receptors and M1-5 mAChRs inhibits conditioned avoidance in the shuttle box test in dogs (ED50 2.77 mg/kg) inhibits apomorphine-induced emesis in dogs (ED50 0.69 mg/kg) induces tachycardia increases blood levels of norepinephrine and temporarily decreases systolic and diastolic blood pressure which revert to baseline within one minute in normotensive dogs at 0.5-5 mg/kg
Cayman Chemical SalIn SodIM Phosphate EDTA
A PAK1 inhibitor (IC50 0.33 nM) selective for PAK1 over a panel of 117 kinases at 100 nM binds to PAK1 and PAK2 (Kd 0.28 and 0.32 nM respectively) inhibits S. enterica infection in HAP1 cells at 10 UM inhibits cell death induced by an antibody targeting Siglec-8 in IL-5-stimulated primary human eosinophils (IC50 59 nM)
Cayman Chemical EDTA Stock SolutIon500 m500mL
An inhibitor of Factor XIa (IC50 0.92 nM) greater than 1000-fold selective for Factor Xa over FVIIa FIXa FXa thrombin urokinase tissue plasminogen activator and plasmin increases clotting time in isolated human plasma (EC150 0.2 UM) reduces thrombus weight in a rabbit model of thrombosis induced by ferric chloride injury of the carotid artery
Sigma Aldrich Fine Chemicals Biosciences Heparin-biotin sodium salt10MG
Heparin-biotin sodium salt10MG
Cayman Chemical TrIsBorate EDTA Stock SolutI
A P2X7 receptor antagonist inhibits ATP-induced dye uptake in HEK293 cells expressing human purinergic P2X7 receptors (IC50 22.4 nM) inhibits common lancehead (B. atrox) venom proteolysis in a concentration-dependent manner inhibits ATP-induced IL-1B secretion in human THP-1 monocytes and primary mouse peritoneal macrophages (IC50s 9.8 and 11.2 nM respectively) inhibits common lancehead (B. atrox) and jararaca (B. jararaca) venom-induced skin hemorrhage in mice when intradermally administered at 3 mg/kg inhibits carrageenan-induced paw edema in mice at 0.01 to 1 mg/kg
Cayman Chemical HeparIn-bIndng PeptIdetrIf 5mg
An inhibitor of ATM kinase (IC50 0.78 nM) selective for ATM over ATR PI3K mTOR and DNA-PK (IC50s 30 12 16 and 29.9 UM respectively) sensitizes glioma cells expressing mutant but not wild-type p53 to ionizing radiation reduces the growth of brain metastases and increases survival in an NCI H2228 mouse xenograft model at 20 mg/kg twice daily p.o. in combination with radiation
Cayman Chemical TrIsACTAte EDTA Stock Solut
A photocontrollable NO donor for in cellulo and ex vivo use composed of rosamine and N-nitrosoaminophenol Upon excitation of rosamine between 530-590 nm photoinduced electron transfer from the NO-releasing moiety occurs forming an unstable phenoxy radical which then releases NO to form a stable quinoneimine product
Cayman Chemical TrIs-EDTA Stock SolutIon10X 1L
An ionizable cationic lipid (pKa 6.39) has been used in the generation of LNPs for siRNA delivery in vitro and in vivo LNPs containing O12-D3-I3 and encapsulating ferrocene and siRNA targeting Nrf2 or system xc- cystine/glutamate transporter decrease viability of HepG2 cells LNPs containing O12-D3-I3 and an mRNA reporter selectively accumulate in the tumor and liver over the lungs kidneys spleen and heart in mice LNPs containing O12-D3-I3 and encapsulating ferrocene and siRNA targeting Nrf2 or system xc- cystine/glutamate transporter reduce tumor growth and volume in an MCF-7 breast cancer mouse xenograft model LNPs containing O12-D3-I3 and encapsulating siRNA targeting Factor VII decrease hepatocyte Factor VII mRNA levels in mice
Innovative Research Inc Rat Sprague Dawley Plasma Na Heparin 50ml
Rat Sprague Dawley Plasma from Innovative Research is manufactured using whole blood collections from Sprague Dawley rats. This product is manufactured in large batches, and is not available with any special instructions - if you require custom-collected material, please see our Innovative Grade US Origin Rat Sprague Dawley Plasma.